The global lyophilization/freeze drying equipment market size was valued at US$ 2,116.5 million in 2017, and is expected to exhibit a robust CAGR of 6.5% over the forecast period (2018 – 2026).
Freeze drying is the removal of ice or other frozen solvents from a material through the process of sublimation and the removal of bound water molecules through the process of desorption. It is an excellent method of preserving a wide variety of heat-sensitive materials such as proteins, microbes, pharmaceuticals, tissues, and plasma. Lyophilization is also used in the biotechnology and biomedical industries to preserve vaccines, blood samples, purified proteins, and other biological material. This process provides an efficient technique for preservation of temperature sensitive and biologic products such as proteins, enzymes, blood plasma, and vaccines.
Increasing number of drug development process and biopharmaceutical research is a major factor augmenting growth of the market as lyophilization is widely used for pharmaceuticals/ biopharmaceuticals to improve stability, thereby achieve adequate shelf life. Lyophilization or freeze-drying is vital process in developing and manufacturing unstable and sensitive pharmaceuticals, as they aid in introducing new pharmaceutical to market. Biopharmaceuticals are produced by genetically modified organisms and are temperature sensitive complex molecules, which require gentle freeze drying with the lyophilisation process to attain adequate shelf life. According to the survey by Martin Christ GmbH, around 60% of the biopharmaceutical products, such as special cancer treatment substances and antibodies, require freeze drying for attaining efficient results in clinical trials. Also, increasing number of global biopharmaceutical companies is expected to boost market growth over the forecast period as these companies are highly dependent on lyophilization due to wide availability of biologics, which include vaccines, blood components, somatic cells, gene therapy, tissues, and recombinant therapeutic proteins.
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According to Pharmaceutical Research and Manufacturers of America (PhRMA), 2016, biopharmaceutical companies are focused on developing drugs for treatment of diseases such as cancers which has 1,919 medicines in development, 563 medicines for cardiovascular diseases and 1,123 medicines for immunological disorders, which require recombinant proteins for various stages for drug development. Also, according to Pharmaceutical Research and Manufacturers of America (PhRMA), 2016, member companies invested an estimated US$ 58.8 billion in research and development in 2015, which was the majority of all biopharmaceutical R&D spending in the U.S.
Moreover, according to the survey by Future Science Group, 2016, injectable products are majorly selected as formulations for new therapeutics. However, liquid formulations often enhances degradation through hydrolysis. Thus, lyophilization/ freeze-drying is regularly used in pharmaceutical manufacture to reduce water activity and assure product stability.
Major players operating in the global lyophilization/freeze drying equipment market include Thermo Fisher Scientific, Inc., Millrock Technology Inc., Zirbus Technology GmbH, SP Scientific, Azbil Telstar, S.L., Biopharma Process Systems Ltd., LTE Scientific Ltd., Martin Christ GmbH, GEA Group, and Cuddon Freeze Dry.
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