Dermal regeneration template is a two-layered skin regeneration system. The outer layer of dermal regeneration template is made of thin silicone film act as the epidermis of skin. The outer layer of dermal regeneration template helps in protecting wound from infection and controls in loss of both heat and moisture. The outer collagen Glycosaminoglycan (GAG) thermal layer functions as a biodegradable template that helps in regeneration of dermal tissue neodermis by the body. The inner layer of dermal regeneration template is made of complex matrix of cross-linked fibers.
The porous material of the template helps in regeneration of skin. The cross-linked fiber material of dermal regeneration template acts a scaffold for the re-growth of skin layer. Once the dermal skin layer is regenerated the outer layer of template is removed and is replaced with a thin epidermal skin graft. This procedure leaves the wound to a flexible, growing and allows permanent regeneration of skin.
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The global dermal regeneration template market has only one FDA approved product from Integra LifeScience. The growing research related to innovation in material and design is expected to penetrate many companies in the market. In 2016, a research funded by Welcome Trust described a novel approach to increase the thickness of elastic- layered fiber for geriatric patients and created a hybrid of Integra dermal regeneration template.
Recently, In January 2016, Integra LifeSciences received FDA approval for treatment of Chronic Diabetic Foot Ulcers (DFU) with dermal regeneration template. The application of this template is typically completed in two operative sessions involving the product applied to the excision sites and the second procedure performed 3 to 6 weeks after the placement of product to remove silicone layer and for an epidermal autograft applied to the neodermis.
The increasing cases of burns and awareness among the population of low and middle income countries provides opportunity for dermal regeneration template industry.
In 2010, the U.S. Department of Health & Human Services initiated medical countermeasures (MCMs) program, aimed to improve burn treatment for mass causality. The increasing research fund and grants associated for burn research is creating opportunity for dermal regeneration template manufacturers to come up with products with more innovations. American burn association (ABA) is one of such organization of the U.S. that offers awards, grants and fellowship opportunities to practitioners for education, prevention and rehabilitation of burn.
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The growing usage of skin grafts and skin replacement substitutes are expected to act as a restrain to the global dermal regeneration market. Dermal regeneration template usage in chemical, radiation or electrical burns are limited and can only be used after thorough evaluation by surgeon.
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